Data

Data Explorations

Our image data can be viewed at high resolution online (without download), via Minerva. In Minerva, viewers can annotate and share regions of interest, pan and zoom to explore different levels of detail, and view different subsets of markers. Minerva stories have three main categories:

Automated stories provide basic image viewing with automatic rendering settings, enabling rapid, lightweight sharing of highly multiplexed images, without download.

Curated stories extend the automated stories, adding a quality control step to remove failed markers, ensure appropriate channel intensity settings, and provide metadata about the underlying sample and image.

Narrated stories go a step further, using multi-step narrations to walk a viewer through key features of the data. Narrated stories distill the multidisciplinary knowledge encompassed by each atlas dataset into a single product that grounds the scientific analyses in the underlying data and metadata.

Narrated Minerva Stories

TNBC PDX (HCI-004) tumor: Vehicle Treatment

TNBC PDX (HCI-004) tumor: EZH2i/AKTi Combo Treatment Day 1

TNBC PDX (HCI-004) tumor: EZH2i/AKTi Combo Treatment Day 2

TNBC PDX (HCI-004) tumor: EZH2i/AKTi Combo Treatment Day 30

Nuclear envelope atypia and rupture in human glioblastoma

Multimodal spatial profiling of colorectal cancer using Orion

Graphical Abstract - Multiplexed 3D atlas of state transitions and immune interactions in colorectal cancer

Pathological annotations - Multiplexed 3D atlas of state transitions and immune interactions in colorectal cancer - CRC01

Exploring the Stages of Tuberculosis Granulomas

Clinical Features of Tuberculosis Granulomas

Deep Exploration of a Primary Melanoma (MEL 1 Full Story)

Introduction to the MEL Atlas (MEL 1 Abstract)

Two Ways of Immune Evasion in Early Melanoma (for non-experts)

Murine Models of Lung Adenocarcinoma

Primary Squamous Cell Carcinoma of the Lung - CyCIF (Lung 3)

Temporal and spatial topography of cell proliferation in cancer

Colorectal cancer pilot - CRC01

A8_right_ventricle

A7_lateral_left_ventricle

A6_posterior_left_ventricle

A5_posterior_left_ventricle

A4_posterior_left_ventricle

A3_interventricular_septum

A2_anterior_left_ventricle

A20_left_circumflex_artery

A1_left_atrium

A19_left_anterior_descending_artery

A18_left_anterior_descending_artery

A17_mid_distal_right_coronary_artery

Patient 2 - Melanoma in situ, invasive melanoma, precursor field and inflammatory regression

Ovarian Cancer with Annotation - LSP15343

Ovarian Cancer with Annotation - LSP15327

BRCA wild-type TNBC vs BRCA1-associated TNBC

Clinical Benefit - Cisplatin Biopsy

Clinical Benefit - Cis Wee1i Biopsy

No Clinical Benefit - Cis Wee1i Biopsy

No Clinical Benefit - Cisplatin Biopsy

HSF1 phase transition mediates stress adaptation and cell fate decisions

Genetically engineered mouse model of lung adenocarcinoma

Pancreatic ductal adenocarcinoma (PDAC) and adjacent normal tissue (Figure 7)

Molecular heterogeneity in glioblastoma (Figure 11 and 12)

Temporal and spatial topography of cell proliferation in cancer

Tonsil - Classical features - CyCIF

Data analysis of primary lung cancer (Lung 3)

Lung squamous cell carcinoma metastasis to the brain (Lung 2)

Plexiform Schwannoma (Spinal Nerve Root)

Plexiform Schwannoma (Soft Tissue)

Intraneural Schwannoma (Finger)

Plexiform Schwannoma (Finger)

Plexiform Schwannoma (Larynx)

Schwannoma (Spinal Nerve Root)

Vestibular Schwannoma 2

Meningioma

Vestibular Schwannoma 1

Meningioma

Back to Narrated Data To Automated Data

Curated Minerva Stories

Curated stories provide access to images that have undergone a quality control step to remove failed markers, ensure appropriate channel intensity settings, and provide metadata about the underlying sample and image. Click the Minerva story icon for an interactive view of the full-resolution images.

Tonsil - 3D CyCIF - LSP13357

STIC-TR5 - 3D CyCIF - LSP18251

STIC-TR4 - 3D CyCIF - LSP18251

STIC-TR3 - 3D CyCIF - LSP18251

Melanoma VGP - 3D CyCIF - LSP13625

Melanoma MIS - 3D CyCIF - LSP13625

Melanoma VGP - 3D CyCIF - LSP13626

Metastatic melanoma - 3D CyCIF - LSP22409

Lung metastasis (lungMET) - 3D CyCIF - LSP22408

Glioblastoma (GBM)- 3D CyCIF - LSP17378

Cell State Dependent Effects of Bmal1 on Melanoma Immunity and Tumorigenicity

Melanoma in-situ with 3D imaging

TB - MIBI - Patient 15-2

TB - MIBI - Patient 15-1

TB - MIBI - Patient 14-2

TB - MIBI - Patient 14-1

TB - MIBI - Patient 13-2

TB - MIBI - Patient 13-1

TB - MIBI - Patient 12-2

TB - MIBI - Patient 12-1

TB - MIBI - Patient 11-2

TB - MIBI - Patient 11-1

TB - MIBI - Patient 10-2

TB - MIBI - Patient 10-1

TB - MIBI - Patient 9-2

TB - MIBI - Patient 9-1

TB - MIBI - Patient 8-2

TB - MIBI - Patient 8-1

TB - MIBI - Patient 7-2

TB - MIBI - Patient 7-1

TB - MIBI - Patient 6-2

TB - MIBI - Patient 6-1

TB - MIBI - Patient 5-2

TB - MIBI - Patient 5-1

TB - MIBI - Patient 4-2

TB - MIBI - Patient 4-1

TB - MIBI - Patient 3-2

TB - MIBI - Patient 3-1

TB - MIBI - Patient 2-2

TB - MIBI - Patient 2-1

TB - MIBI - Patient 1-2

TB - MIBI - Patient 1-1

All CyCIF sections of CRC01 (Z-stack)

TMA of 16 Breast Cancer Samples and Normal Tissue (BC03)

Lung Adenocarcinoma Metastasis to Lymph Node

Longitudinal study of metastatic melanoma - Day 92 - Skin, right upper lip (T21)

Longitudinal study of metastatic melanoma - Day 92 - Skin, left neck (T20)

Longitudinal study of metastatic melanoma - Day 92 - Skin, left groin (T19)

Longitudinal study of metastatic melanoma - Day 76 - Skin, left leg (T15)

Longitudinal study of metastatic melanoma - Day 76 - Skin, right nasal labial fold (T17)

Longitudinal study of metastatic melanoma - Day 76 - Skin, right neck (T16)

Longitudinal study of metastatic melanoma - Day 62 - Skin, left wrist (T14)

Longitudinal study of metastatic melanoma - Day 62 - Skin, right neck (T13)

Longitudinal study of metastatic melanoma - Day 39 - Skin, left arm (T12)

Longitudinal study of metastatic melanoma - Day 39 - Skin, posterior neck (T10)

Longitudinal study of metastatic melanoma - Day 39 - Skin, left scalp (T11)

Longitudinal study of metastatic melanoma - Day 39 - Skin, right scalp (T9)

Longitudinal study of metastatic melanoma - Day 27 - Skin, right ear (T8)

Longitudinal study of metastatic melanoma - Day 27 - Skin, left brow (T7)

Longitudinal study of metastatic melanoma - Day 27 - Skin, chin (T5)

Longitudinal study of metastatic melanoma - Day 27 - Skin, upper lip (T6)

Longitudinal study of metastatic melanoma - Day -22 - Skin, nasal labial fold (T4)

Longitudinal study of metastatic melanoma - Day 1028 - Jejunal resection (R1)

Longitudinal study of metastatic melanoma - Day 109 - skin, left ring finger (T22)

Longitudinal study of metastatic melanoma - Day 83 - skin left shoulder (T18)

Longitudinal study of metastatic melanoma - Day 1862 - skin left neck (R3.2)

Longitudinal study of metastatic melanoma - Day 1849 - skin left neck (R3.1)

Ovarian cancer with metadata - LSP15343

CK1 (BRCA wildtype)

CK2 (BRCA wildtype)

CK3_R (BRCA wildtype)

CK4_P (BRCA wildtype)

CK4_R (BRCA wildtype)

CK5 (BRCA wildtype)

CK6 (BRCA wildtype)

CK7 (BRCA wildtype)

CK8 (BRCA wildtype)

CK9 (BRCA wildtype)

CK10 (BRCA wildtype)

CK11 (BRCA wildtype)

CK12 (BRCA wildtype)

CK13 (BRCA wildtype)

CK14 (BRCA wildtype)

CK15 (BRCA wildtype)

CK16 (BRCA wildtype)

CK17_M (BRCA wildtype)

CK18_P (BRCA wildtype)

CK19_BCC (BRCA wildtype)

CK19_BCC2 (BRCA wildtype)

CK20 (BRCA wildtype)

CK21 (BRCA wildtype)

CK22 (BRCA wildtype)

CK23 (BRCA wildtype)

CK24 (BRCA wildtype)

CK25_R (BRCA wildtype)

CK26 (BRCA wildtype)

W2BC_3 (BRCA wildtype)

W8B_4 (BRCA wildtype)

K1 (BRCA mutant)

K2 (BRCA mutant)

K3 (BRCA mutant)

K4 (BRCA mutant)

K5 (BRCA mutant)

K6 (BRCA mutant)

K7 (BRCA mutant)

K8 (BRCA mutant)

K9 (BRCA mutant)

K10 (BRCA mutant)

K11 (BRCA mutant)

K12 (BRCA mutant)

K13 (BRCA mutant)

K14 (BRCA mutant)

K15 (BRCA mutant)

K16 (BRCA mutant)

K17 (BRCA mutant)

K18 (BRCA mutant)

K19 (BRCA mutant)

K20 (BRCA mutant)

K21 (BRCA mutant)

K22 (BRCA mutant)

K23 (BRCA mutant)

K24 (BRCA mutant)

K26 (BRCA mutant)

K27 (BRCA mutant)

All 25 CyCIF sections from CRC01 (array)

All 22 H&E sections from CRC01 (array)

Metastatic melanoma lesion and adjacent benign tissue (Figure 2)

CyCIF of TMA with normal and tumor tissue (Figure 10)

Tonsil IHC

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Automated Minerva Stories

Automated stories provide basic image viewing with automatic rendering settings, enabling rapid, lightweight sharing of highly multiplexed images, without download. Click the Minerva story icon for an interactive view of the full-resolution images.

Orion CRC40 - overview - Lin, Chen, Campton et al., 2023

Orion CRC39 - overview - Lin, Chen, Campton et al., 2023

Orion CRC38 - overview - Lin, Chen, Campton et al., 2023

Orion CRC37 - overview - Lin, Chen, Campton et al., 2023

Orion CRC36 - overview - Lin, Chen, Campton et al., 2023

Orion CRC35 - overview - Lin, Chen, Campton et al., 2023

Orion CRC34 - overview - Lin, Chen, Campton et al., 2023

Orion CRC33_02 - overview - Lin, Chen, Campton et al., 2023

Orion CRC33_01 - overview - Lin, Chen, Campton et al., 2023

Orion CRC32 - overview - Lin, Chen, Campton et al., 2023

Orion CRC31 - overview - Lin, Chen, Campton et al., 2023

Orion CRC30 - overview - Lin, Chen, Campton et al., 2023

Orion CRC29 - overview - Lin, Chen, Campton et al., 2023

Orion CRC28 - overview - Lin, Chen, Campton et al., 2023

Orion CRC27 - overview - Lin, Chen, Campton et al., 2023

Orion CRC26 - overview - Lin, Chen, Campton et al., 2023

Orion CRC25 - overview - Lin, Chen, Campton et al., 2023

Orion CRC24 - overview - Lin, Chen, Campton et al., 2023

Orion CRC23 - overview - Lin, Chen, Campton et al., 2023

Orion CRC21 - overview - Lin, Chen, Campton et al., 2023

Orion CRC08 - overview - Lin, Chen, Campton et al., 2023

Orion CRC20 - overview - Lin, Chen, Campton et al., 2023

Orion CRC19 - overview - Lin, Chen, Campton et al., 2023

Orion CRC18 - overview - Lin, Chen, Campton et al., 2023

Orion CRC17 - overview - Lin, Chen, Campton et al., 2023

Orion CRC16 - overview - Lin, Chen, Campton et al., 2023

Orion CRC15 - overview - Lin, Chen, Campton et al., 2023

Orion CRC14 - overview - Lin, Chen, Campton et al., 2023

Orion CRC13 - overview - Lin, Chen, Campton et al., 2023

Orion CRC12 - overview - Lin, Chen, Campton et al., 2023

Orion CRC11 - overview - Lin, Chen, Campton et al., 2023

Orion CRC10 - overview - Lin, Chen, Campton et al., 2023

Orion CRC09 - overview - Lin, Chen, Campton et al., 2023

Orion CRC07 - overview - Lin, Chen, Campton et al., 2023

Orion CRC06 - overview - Lin, Chen, Campton et al., 2023

Orion CRC05 - overview - Lin, Chen, Campton et al., 2023

Orion CRC04 - overview - Lin, Chen, Campton et al., 2023

Orion CRC03 - overview - Lin, Chen, Campton et al., 2023

Orion CRC02 - overview - Lin, Chen, Campton et al., 2023

Orion CRC01 - overview - Lin, Chen, Campton et al., 2023

Lung adenocarcinoma - P138007

Lung adenocarcinoma - P137974

Lung adenocarcinoma - P137941

Lung adenocarcinoma - P137905

Lung adenocarcinoma - P137757

Lung adenocarcinoma - P137753

Lung adenocarcinoma - P137591

Lung adenocarcinoma - P136690

Lung adenocarcinoma - P133537

Lung adenocarcinoma - P132666

Lung adenocarcinoma - P132630

Lung adenocarcinoma - P132115

MEL13-2-1 - overview - Nirmal, Maliga, Vallius, Sorger et al., 2021

MEL13-2-0 - H&E - overview - Nirmal, Maliga, Vallius, Sorger et al., 2021

MEL13-1-1 - overview - Nirmal, Maliga, Vallius, Sorger et al., 2021

MEL13-1-0 - H&E - overview - Nirmal, Maliga, Vallius, Sorger et al., 2021

MEL12-1-1 - overview - Nirmal, Maliga, Vallius, Sorger et al., 2021

MEL12-1-0 - H&E - overview - Nirmal, Maliga, Vallius, Sorger et al., 2021

MEL11-1-1 - overview - Nirmal, Maliga, Vallius, Sorger et al., 2021

MEL11-1-0 - H&E - overview - Nirmal, Maliga, Vallius, Sorger et al., 2021

MEL10-1-1 - overview - Nirmal, Maliga, Vallius, Sorger et al., 2021

MEL10-1-0 - H&E - overview - Nirmal, Maliga, Vallius, Sorger et al., 2021

MEL09-1-1 - overview - Nirmal, Maliga, Vallius, Sorger et al., 2021

MEL09-1-0 - H&E - overview - Nirmal, Maliga, Vallius, Sorger et al., 2021

MEL08-1-1 - overview - Nirmal, Maliga, Vallius, Sorger et al., 2021

MEL08-1-0 - H&E - overview - Nirmal, Maliga, Vallius, Sorger et al., 2021

MEL07-1-1 - overview - Nirmal, Maliga, Vallius, Sorger et al., 2021

MEL07-1-0 - H&E - overview - Nirmal, Maliga, Vallius, Sorger et al., 2021

MEL06-1-1 - overview - Nirmal, Maliga, Vallius, Sorger et al., 2021

MEL06-1-0 - H&E - overview - Nirmal, Maliga, Vallius, Sorger et al., 2021

MEL05-1-1 - overview - Nirmal, Maliga, Vallius, Sorger et al., 2021

MEL05-1-0 - H&E - overview - Nirmal, Maliga, Vallius, Sorger et al., 2021

MEL04-1-1 - overview - Nirmal, Maliga, Vallius, Sorger et al., 2021

MEL04-1-0 - H&E - overview - Nirmal, Maliga, Vallius, Sorger et al., 2021

MEL03-1-1 - overview - Nirmal, Maliga, Vallius, Sorger et al., 2021

MEL03-1-0 - H&E - overview - Nirmal, Maliga, Vallius, Sorger et al., 2021

MEL02-1-1 - overview - Nirmal, Maliga, Vallius, Sorger et al., 2021

MEL02-1-0 - H&E - overview - Nirmal, Maliga, Vallius, Sorger et al., 2021

MEL01-3-1 - overview - Nirmal, Maliga, Vallius, Sorger et al., 2021

MEL01-3-0 - H&E - overview - Nirmal, Maliga, Vallius, Sorger et al., 2021

MEL01-2-1 - overview - Nirmal, Maliga, Vallius, Sorger et al., 2021

MEL01-2-0 - H&E - overview - Nirmal, Maliga, Vallius, Sorger et al., 2021

MEL01-1-6 - overview - Nirmal, Maliga, Vallius, Sorger et al., 2021

MEL01-1-5 - overview - Nirmal, Maliga, Vallius, Sorger et al., 2021

MEL01-1-4 - overview - Nirmal, Maliga, Vallius, Sorger et al., 2021

MEL01-1-3 - overview - Nirmal, Maliga, Vallius, Sorger et al., 2021

MEL01-1-1 - overview - Nirmal, Maliga, Vallius, Sorger et al., 2021

MEL01-1-0 - H&E - overview - Nirmal, Maliga, Vallius, Sorger et al., 2021

Longitudinal study of metastatic melanoma - Autopsy - Right adrenal (AV1)

Longitudinal study of metastatic melanoma - Autopsy - Subcutaneous lesion, left temporal bone (AS4)

Longitudinal study of metastatic melanoma - Autopsy - Subcutaneous lesion, left scalp (AS3)

Longitudinal study of metastatic melanoma - Autopsy - Subcutaneous lesion, left inguinal region (AS2)

Longitudinal study of metastatic melanoma - Autopsy - Subcutaneous lesion, left mastoid (AS1)

Longitudinal study of metastatic melanoma - Autopsy - Lung, left lower lobe (AL4)

Longitudinal study of metastatic melanoma - Autopsy - Lung, left upper lobe (AL3)

Longitudinal study of metastatic melanoma - Autopsy - Lung, right upper lobe (AL2)

Longitudinal study of metastatic melanoma - Autopsy - Lung, right lower lobe (AL1)

Patient 1 - Melanoma with precursor fields

Patient 2 - Inflammatory regression and brisk TILs

Patient 2 - Melanoma in situ, invasive and polypoid melanoma

LSP16696

LSP16697

LSP16698

LSP16699

LSP16814

BRCA1-associated-9

BRCA1-associated TNBC 8

BRCA1-associated TNBC 7

BRCA1-associated TNBC 6

BRCA1-associated TNBC 5

BRCA1-associated TNBC 4

BRCA1-associated TNBC 3

BRCA1-associated TNBC 2

BRCA1-associated-10

BRCA1-associated TNBC 1

BRCA wild-type TNBC (BRCA-WT-6)

BRCA wild-type TNBC (BRCA-WT-5)

BRCA wild-type TNBC (BRCA-WT-4)

BRCA wild-type TNBC (BRCA-WT-3)

BRCA wild-type TNBC (BRCA-WT-2)

BRCA wild-type TNBC (BRCA-WT-1)

CRC18 - H&E - overview - Lin, Wang, Coy et al., 2021

CRC17 - overview - Lin, Wang, Coy et al., 2021

CRC17 - H&E - overview - Lin, Wang, Coy et al., 2021

CRC16 - overview - Lin, Wang, Coy et al., 2021

CRC16 - H&E - overview - Lin, Wang, Coy et al., 2021

CRC15 - overview - Lin, Wang, Coy et al., 2021

CRC15 - H&E - overview - Lin, Wang, Coy et al., 2021

CRC14 - overview - Lin, Wang, Coy et al., 2021

CRC14 - H&E - overview - Lin, Wang, Coy et al., 2021

CRC13 - overview - Lin, Wang, Coy et al., 2021

CRC13 - H&E - overview - Lin, Wang, Coy et al., 2021

CRC12 - overview - Lin, Wang, Coy et al., 2021

CRC12 - H&E - overview - Lin, Wang, Coy et al., 2021

CRC11 - overview - Lin, Wang, Coy et al., 2021

CRC11 - H&E - overview - Lin, Wang, Coy et al., 2021

CRC10 - overview - Lin, Wang, Coy et al., 2021

CRC10 - H&E - overview - Lin, Wang, Coy et al., 2021

CRC08 - overview - Lin, Wang, Coy et al., 2021

CRC09 - H&E - overview - Lin, Wang, Coy et al., 2021

CRC08 - overview - Lin, Wang, Coy et al., 2021

CRC08 - H&E - overview - Lin, Wang, Coy et al., 2021

CRC07 - overview - Lin, Wang, Coy et al., 2021

CRC07 - H&E - overview - Lin, Wang, Coy et al., 2021

CRC06 - overview - Lin, Wang, Coy et al., 2021

CRC06 - H&E - overview - Lin, Wang, Coy et al., 2021

CRC05 - overview - Lin, Wang, Coy et al., 2021

CRC05 - H&E - overview - Lin, Wang, Coy et al., 2021

CRC04 - overview - Lin, Wang, Coy et al., 2021

CRC04 - H&E - overview - Lin, Wang, Coy et al., 2021

CRC03 - overview - Lin, Wang, Coy et al., 2021

CRC03 - H&E - overview - Lin, Wang, Coy et al., 2021

CRC02 - overview - Lin, Wang, Coy et al., 2021

CRC02 - H&E - overview - Lin, Wang, Coy et al., 2021

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