Data Explorations

Our image data can be viewed at high resolution online (without download), via Minerva. In Minerva, viewers can annotate and share regions of interest, pan and zoom to explore different levels of detail, and view different subsets of markers. Minerva stories have three main categories:

  • Automated stories provide basic image viewing with automatic rendering settings, enabling rapid, lightweight sharing of highly multiplexed images, without download.
  • Curated stories extend the automated stories, adding a quality control step to remove failed markers, ensure appropriate channel intensity settings, and provide metadata about the underlying sample and image.
  • Narrated stories go a step further, using multi-step narrations to walk a viewer through key features of the data. Narrated stories distill the multidisciplinary knowledge encompassed by each atlas dataset into a single product that grounds the scientific analyses in the underlying data and metadata.

Narrated Minerva Stories

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ERS-Low sample: enhanced immune infiltration and antigen presentation
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ERS-High sample: limited immune infiltration and reduced antigen presentation
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TNBC PDX (HCI-004) tumor: Vehicle Treatment
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TNBC PDX (HCI-004) tumor: EZH2i/AKTi Combo Treatment Day 1
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TNBC PDX (HCI-004) tumor: EZH2i/AKTi Combo Treatment Day 2
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TNBC PDX (HCI-004) tumor: EZH2i/AKTi Combo Treatment Day 30
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Nuclear envelope atypia and rupture in human glioblastoma
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Multimodal spatial profiling of colorectal cancer using Orion
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Graphical Abstract - Multiplexed 3D atlas of state transitions and immune interactions in colorectal cancer
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Pathological annotations - Multiplexed 3D atlas of state transitions and immune interactions in colorectal cancer - CRC01
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Exploring the Stages of Tuberculosis Granulomas
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Clinical Features of Tuberculosis Granulomas
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Deep Exploration of a Primary Melanoma (MEL 1 Full Story)
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Introduction to the MEL Atlas (MEL 1 Abstract)
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Two Ways of Immune Evasion in Early Melanoma (for non-experts)
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Murine Models of Lung Adenocarcinoma
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Primary Squamous Cell Carcinoma of the Lung - CyCIF (Lung 3)
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Temporal and spatial topography of cell proliferation in cancer
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Colorectal cancer pilot - CRC01
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A8_right_ventricle
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A7_lateral_left_ventricle
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A6_posterior_left_ventricle
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A5_posterior_left_ventricle
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A4_posterior_left_ventricle
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A3_interventricular_septum
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A2_anterior_left_ventricle
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A20_left_circumflex_artery
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A1_left_atrium
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A19_left_anterior_descending_artery
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A18_left_anterior_descending_artery
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A17_mid_distal_right_coronary_artery
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Patient 2 - Melanoma in situ, invasive melanoma, precursor field and inflammatory regression
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Ovarian Cancer with Annotation - LSP15343
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Ovarian Cancer with Annotation - LSP15327
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BRCA wild-type TNBC vs BRCA1-associated TNBC
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Clinical Benefit - Cisplatin Biopsy
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Clinical Benefit - Cis Wee1i Biopsy
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No Clinical Benefit - Cis Wee1i Biopsy
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No Clinical Benefit - Cisplatin Biopsy
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HSF1 phase transition mediates stress adaptation and cell fate decisions
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Genetically engineered mouse model of lung adenocarcinoma
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Pancreatic ductal adenocarcinoma (PDAC) and adjacent normal tissue (Figure 7)
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Molecular heterogeneity in glioblastoma (Figure 11 and 12)
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Temporal and spatial topography of cell proliferation in cancer
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Tonsil - Classical features - CyCIF
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Data analysis of primary lung cancer (Lung 3)
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Lung squamous cell carcinoma metastasis to the brain (Lung 2)
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Plexiform Schwannoma (Spinal Nerve Root)
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Plexiform Schwannoma (Soft Tissue)
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Plexiform Schwannoma (Soft Tissue)
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Intraneural Schwannoma (Finger)
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Plexiform Schwannoma (Finger)
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Plexiform Schwannoma (Larynx)
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Plexiform Schwannoma (Larynx)
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Schwannoma (Spinal Nerve Root)
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Schwannoma (Spinal Nerve Root)
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Schwannoma (Spinal Nerve Root)
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Vestibular Schwannoma 2
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Meningioma
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Vestibular Schwannoma 1
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Vestibular Schwannoma 1
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Meningioma

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Curated Minerva Stories

Curated stories provide access to images that have undergone a quality control step to remove failed markers, ensure appropriate channel intensity settings, and provide metadata about the underlying sample and image. Click the Minerva story icon for an interactive view of the full-resolution images.

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Tonsil - 3D CyCIF - LSP13357
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STIC-TR5 - 3D CyCIF - LSP18251
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STIC-TR4 - 3D CyCIF - LSP18251
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STIC-TR3 - 3D CyCIF - LSP18251
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Melanoma VGP - 3D CyCIF - LSP13625
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Melanoma MIS - 3D CyCIF - LSP13625
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Melanoma VGP - 3D CyCIF - LSP13626
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Metastatic melanoma - 3D CyCIF - LSP22409
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Lung metastasis (lungMET) - 3D CyCIF - LSP22408
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Glioblastoma (GBM)- 3D CyCIF - LSP17378
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Cell State Dependent Effects of Bmal1 on Melanoma Immunity and Tumorigenicity
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Melanoma in-situ with 3D imaging
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TB - MIBI - Patient 15-2
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TB - MIBI - Patient 15-1
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TB - MIBI - Patient 14-2
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TB - MIBI - Patient 14-1
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TB - MIBI - Patient 13-2
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TB - MIBI - Patient 13-1
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TB - MIBI - Patient 12-2
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TB - MIBI - Patient 12-1
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TB - MIBI - Patient 11-2
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TB - MIBI - Patient 11-1
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TB - MIBI - Patient 10-2
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TB - MIBI - Patient 10-1
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TB - MIBI - Patient 9-2
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TB - MIBI - Patient 9-1
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TB - MIBI - Patient 8-2
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TB - MIBI - Patient 8-1
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TB - MIBI - Patient 7-2
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TB - MIBI - Patient 7-1
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TB - MIBI - Patient 6-2
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TB - MIBI - Patient 6-1
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TB - MIBI - Patient 5-2
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TB - MIBI - Patient 5-1
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TB - MIBI - Patient 4-2
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TB - MIBI - Patient 4-1
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TB - MIBI - Patient 3-2
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TB - MIBI - Patient 3-1
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TB - MIBI - Patient 2-2
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TB - MIBI - Patient 2-1
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TB - MIBI - Patient 1-2
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TB - MIBI - Patient 1-1
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All CyCIF sections of CRC01 (Z-stack)
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TMA of 16 Breast Cancer Samples and Normal Tissue (BC03)
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Lung Adenocarcinoma Metastasis to Lymph Node
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Longitudinal study of metastatic melanoma - Day 92 - Skin, right upper lip (T21)
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Longitudinal study of metastatic melanoma - Day 92 - Skin, left neck (T20)
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Longitudinal study of metastatic melanoma - Day 92 - Skin, left groin (T19)
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Longitudinal study of metastatic melanoma - Day 76 - Skin, left leg (T15)
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Longitudinal study of metastatic melanoma - Day 76 - Skin, right nasal labial fold (T17)
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Longitudinal study of metastatic melanoma - Day 76 - Skin, right neck (T16)
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Longitudinal study of metastatic melanoma - Day 62 - Skin, left wrist (T14)
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Longitudinal study of metastatic melanoma - Day 62 - Skin, right neck (T13)
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Longitudinal study of metastatic melanoma - Day 39 - Skin, left arm (T12)
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Longitudinal study of metastatic melanoma - Day 39 - Skin, posterior neck (T10)
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Longitudinal study of metastatic melanoma - Day 39 - Skin, left scalp (T11)
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Longitudinal study of metastatic melanoma - Day 39 - Skin, right scalp (T9)
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Longitudinal study of metastatic melanoma - Day 27 - Skin, right ear (T8)
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Longitudinal study of metastatic melanoma - Day 27 - Skin, left brow (T7)
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Longitudinal study of metastatic melanoma - Day 27 - Skin, chin (T5)
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Longitudinal study of metastatic melanoma - Day 27 - Skin, upper lip (T6)
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Longitudinal study of metastatic melanoma - Day -22 - Skin, nasal labial fold (T4)
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Longitudinal study of metastatic melanoma - Day 1028 - Jejunal resection (R1)
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Longitudinal study of metastatic melanoma - Day 109 - skin, left ring finger (T22)
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Longitudinal study of metastatic melanoma - Day 83 - skin left shoulder (T18)
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Longitudinal study of metastatic melanoma - Day 1862 - skin left neck (R3.2)
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Longitudinal study of metastatic melanoma - Day 1849 - skin left neck (R3.1)
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Ovarian cancer with metadata - LSP15343
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CK1 (BRCA wildtype)
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CK2 (BRCA wildtype)
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CK3_R (BRCA wildtype)
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CK4_P (BRCA wildtype)
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CK4_R (BRCA wildtype)
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CK5 (BRCA wildtype)
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CK6 (BRCA wildtype)
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CK7 (BRCA wildtype)
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CK8 (BRCA wildtype)
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CK9 (BRCA wildtype)
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CK10 (BRCA wildtype)
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CK11 (BRCA wildtype)
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CK12 (BRCA wildtype)
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CK13 (BRCA wildtype)
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CK14 (BRCA wildtype)
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CK15 (BRCA wildtype)
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CK16 (BRCA wildtype)
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CK17_M (BRCA wildtype)
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CK18_P (BRCA wildtype)
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CK19_BCC (BRCA wildtype)
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CK19_BCC2 (BRCA wildtype)
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CK20 (BRCA wildtype)
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CK21 (BRCA wildtype)
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CK22 (BRCA wildtype)
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CK23 (BRCA wildtype)
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CK24 (BRCA wildtype)
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CK25_R (BRCA wildtype)
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CK26 (BRCA wildtype)
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W2BC_3 (BRCA wildtype)
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W8B_4 (BRCA wildtype)
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K1 (BRCA mutant)
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K2 (BRCA mutant)
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K3 (BRCA mutant)
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K4 (BRCA mutant)
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K5 (BRCA mutant)
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K6 (BRCA mutant)
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K7 (BRCA mutant)
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K8 (BRCA mutant)
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K9 (BRCA mutant)
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K10 (BRCA mutant)
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K11 (BRCA mutant)
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K12 (BRCA mutant)
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K13 (BRCA mutant)
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K14 (BRCA mutant)
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K15 (BRCA mutant)
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K16 (BRCA mutant)
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K17 (BRCA mutant)
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K18 (BRCA mutant)
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K19 (BRCA mutant)
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K20 (BRCA mutant)
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K21 (BRCA mutant)
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K22 (BRCA mutant)
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K23 (BRCA mutant)
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K24 (BRCA mutant)
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K26 (BRCA mutant)
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K27 (BRCA mutant)
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All 25 CyCIF sections from CRC01 (array)
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All 22 H&E sections from CRC01 (array)
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Metastatic melanoma lesion and adjacent benign tissue (Figure 2)
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CyCIF of TMA with normal and tumor tissue (Figure 10)
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Tonsil IHC

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Automated Minerva Stories

Automated stories provide basic image viewing with automatic rendering settings, enabling rapid, lightweight sharing of highly multiplexed images, without download. Click the Minerva story icon for an interactive view of the full-resolution images.

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Orion CRC40 - overview - Lin, Chen, Campton et al., 2023
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Orion CRC39 - overview - Lin, Chen, Campton et al., 2023
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Orion CRC38 - overview - Lin, Chen, Campton et al., 2023
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Orion CRC37 - overview - Lin, Chen, Campton et al., 2023
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Orion CRC36 - overview - Lin, Chen, Campton et al., 2023
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Orion CRC35 - overview - Lin, Chen, Campton et al., 2023
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Orion CRC34 - overview - Lin, Chen, Campton et al., 2023
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Orion CRC33_02 - overview - Lin, Chen, Campton et al., 2023
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Orion CRC33_01 - overview - Lin, Chen, Campton et al., 2023
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Orion CRC32 - overview - Lin, Chen, Campton et al., 2023
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Orion CRC31 - overview - Lin, Chen, Campton et al., 2023
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Orion CRC30 - overview - Lin, Chen, Campton et al., 2023
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Orion CRC29 - overview - Lin, Chen, Campton et al., 2023
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Orion CRC28 - overview - Lin, Chen, Campton et al., 2023
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Orion CRC27 - overview - Lin, Chen, Campton et al., 2023
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Orion CRC26 - overview - Lin, Chen, Campton et al., 2023
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Orion CRC25 - overview - Lin, Chen, Campton et al., 2023
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Orion CRC24 - overview - Lin, Chen, Campton et al., 2023
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Orion CRC23 - overview - Lin, Chen, Campton et al., 2023
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Orion CRC21 - overview - Lin, Chen, Campton et al., 2023
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Orion CRC08 - overview - Lin, Chen, Campton et al., 2023
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Orion CRC20 - overview - Lin, Chen, Campton et al., 2023
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Orion CRC19 - overview - Lin, Chen, Campton et al., 2023
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Orion CRC18 - overview - Lin, Chen, Campton et al., 2023
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Orion CRC17 - overview - Lin, Chen, Campton et al., 2023
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Orion CRC16 - overview - Lin, Chen, Campton et al., 2023
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Orion CRC15 - overview - Lin, Chen, Campton et al., 2023
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Orion CRC14 - overview - Lin, Chen, Campton et al., 2023
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Orion CRC13 - overview - Lin, Chen, Campton et al., 2023
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Orion CRC12 - overview - Lin, Chen, Campton et al., 2023
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Orion CRC11 - overview - Lin, Chen, Campton et al., 2023
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Orion CRC10 - overview - Lin, Chen, Campton et al., 2023
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Orion CRC09 - overview - Lin, Chen, Campton et al., 2023
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Orion CRC07 - overview - Lin, Chen, Campton et al., 2023
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Orion CRC06 - overview - Lin, Chen, Campton et al., 2023
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Orion CRC05 - overview - Lin, Chen, Campton et al., 2023
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Orion CRC04 - overview - Lin, Chen, Campton et al., 2023
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Orion CRC03 - overview - Lin, Chen, Campton et al., 2023
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Orion CRC02 - overview - Lin, Chen, Campton et al., 2023
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Orion CRC01 - overview - Lin, Chen, Campton et al., 2023
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Lung adenocarcinoma - P138007
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Lung adenocarcinoma - P137974
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Lung adenocarcinoma - P137941
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Lung adenocarcinoma - P137905
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Lung adenocarcinoma - P137757
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Lung adenocarcinoma - P137753
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Lung adenocarcinoma - P137591
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Lung adenocarcinoma - P136690
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Lung adenocarcinoma - P133537
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Lung adenocarcinoma - P132666
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Lung adenocarcinoma - P132630
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Lung adenocarcinoma - P132115
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MEL13-2-1 - overview - Nirmal, Maliga, Vallius, Sorger et al., 2021
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MEL13-2-0 - H&E - overview - Nirmal, Maliga, Vallius, Sorger et al., 2021
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MEL13-1-1 - overview - Nirmal, Maliga, Vallius, Sorger et al., 2021
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MEL13-1-0 - H&E - overview - Nirmal, Maliga, Vallius, Sorger et al., 2021
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MEL12-1-1 - overview - Nirmal, Maliga, Vallius, Sorger et al., 2021
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MEL12-1-0 - H&E - overview - Nirmal, Maliga, Vallius, Sorger et al., 2021
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MEL11-1-1 - overview - Nirmal, Maliga, Vallius, Sorger et al., 2021
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MEL11-1-0 - H&E - overview - Nirmal, Maliga, Vallius, Sorger et al., 2021
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MEL10-1-1 - overview - Nirmal, Maliga, Vallius, Sorger et al., 2021
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MEL10-1-0 - H&E - overview - Nirmal, Maliga, Vallius, Sorger et al., 2021
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MEL09-1-1 - overview - Nirmal, Maliga, Vallius, Sorger et al., 2021
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MEL09-1-0 - H&E - overview - Nirmal, Maliga, Vallius, Sorger et al., 2021
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MEL08-1-1 - overview - Nirmal, Maliga, Vallius, Sorger et al., 2021
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MEL08-1-0 - H&E - overview - Nirmal, Maliga, Vallius, Sorger et al., 2021
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MEL07-1-1 - overview - Nirmal, Maliga, Vallius, Sorger et al., 2021
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MEL07-1-0 - H&E - overview - Nirmal, Maliga, Vallius, Sorger et al., 2021
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MEL06-1-1 - overview - Nirmal, Maliga, Vallius, Sorger et al., 2021
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MEL06-1-0 - H&E - overview - Nirmal, Maliga, Vallius, Sorger et al., 2021
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MEL05-1-1 - overview - Nirmal, Maliga, Vallius, Sorger et al., 2021
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MEL05-1-0 - H&E - overview - Nirmal, Maliga, Vallius, Sorger et al., 2021
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MEL04-1-1 - overview - Nirmal, Maliga, Vallius, Sorger et al., 2021
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MEL04-1-0 - H&E - overview - Nirmal, Maliga, Vallius, Sorger et al., 2021
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MEL03-1-1 - overview - Nirmal, Maliga, Vallius, Sorger et al., 2021
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MEL03-1-0 - H&E - overview - Nirmal, Maliga, Vallius, Sorger et al., 2021
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MEL02-1-1 - overview - Nirmal, Maliga, Vallius, Sorger et al., 2021
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MEL02-1-0 - H&E - overview - Nirmal, Maliga, Vallius, Sorger et al., 2021
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MEL01-3-1 - overview - Nirmal, Maliga, Vallius, Sorger et al., 2021
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MEL01-3-0 - H&E - overview - Nirmal, Maliga, Vallius, Sorger et al., 2021
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MEL01-2-1 - overview - Nirmal, Maliga, Vallius, Sorger et al., 2021
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MEL01-2-0 - H&E - overview - Nirmal, Maliga, Vallius, Sorger et al., 2021
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MEL01-1-6 - overview - Nirmal, Maliga, Vallius, Sorger et al., 2021
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MEL01-1-5 - overview - Nirmal, Maliga, Vallius, Sorger et al., 2021
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MEL01-1-4 - overview - Nirmal, Maliga, Vallius, Sorger et al., 2021
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MEL01-1-3 - overview - Nirmal, Maliga, Vallius, Sorger et al., 2021
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MEL01-1-1 - overview - Nirmal, Maliga, Vallius, Sorger et al., 2021
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MEL01-1-0 - H&E - overview - Nirmal, Maliga, Vallius, Sorger et al., 2021
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Longitudinal study of metastatic melanoma - Autopsy - Right adrenal (AV1)
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Longitudinal study of metastatic melanoma - Autopsy - Subcutaneous lesion, left temporal bone (AS4)
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Longitudinal study of metastatic melanoma - Autopsy - Subcutaneous lesion, left scalp (AS3)
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Longitudinal study of metastatic melanoma - Autopsy - Subcutaneous lesion, left inguinal region (AS2)
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Longitudinal study of metastatic melanoma - Autopsy - Subcutaneous lesion, left mastoid (AS1)
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Longitudinal study of metastatic melanoma - Autopsy - Lung, left lower lobe (AL4)
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Longitudinal study of metastatic melanoma - Autopsy - Lung, left upper lobe (AL3)
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Longitudinal study of metastatic melanoma - Autopsy - Lung, right upper lobe (AL2)
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Longitudinal study of metastatic melanoma - Autopsy - Lung, right lower lobe (AL1)
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Patient 1 - Melanoma with precursor fields
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Patient 2 - Inflammatory regression and brisk TILs
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Patient 2 - Melanoma in situ, invasive and polypoid melanoma
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LSP16696
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LSP16697
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LSP16698
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LSP16699
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LSP16814
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BRCA1-associated-9
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BRCA1-associated TNBC 8
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BRCA1-associated TNBC 7
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BRCA1-associated TNBC 6
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BRCA1-associated TNBC 5
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BRCA1-associated TNBC 4
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BRCA1-associated TNBC 3
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BRCA1-associated TNBC 2
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BRCA1-associated-10
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BRCA1-associated TNBC 1
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BRCA wild-type TNBC (BRCA-WT-6)
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BRCA wild-type TNBC (BRCA-WT-5)
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BRCA wild-type TNBC (BRCA-WT-4)
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BRCA wild-type TNBC (BRCA-WT-3)
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BRCA wild-type TNBC (BRCA-WT-2)
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BRCA wild-type TNBC (BRCA-WT-1)
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CRC18 - H&E - overview - Lin, Wang, Coy et al., 2021
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CRC17 - overview - Lin, Wang, Coy et al., 2021
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CRC17 - H&E - overview - Lin, Wang, Coy et al., 2021
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CRC16 - overview - Lin, Wang, Coy et al., 2021
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CRC16 - H&E - overview - Lin, Wang, Coy et al., 2021
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CRC15 - overview - Lin, Wang, Coy et al., 2021
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CRC15 - H&E - overview - Lin, Wang, Coy et al., 2021
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CRC14 - overview - Lin, Wang, Coy et al., 2021
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CRC14 - H&E - overview - Lin, Wang, Coy et al., 2021
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CRC13 - overview - Lin, Wang, Coy et al., 2021
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CRC13 - H&E - overview - Lin, Wang, Coy et al., 2021
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CRC12 - overview - Lin, Wang, Coy et al., 2021
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CRC12 - H&E - overview - Lin, Wang, Coy et al., 2021
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CRC11 - overview - Lin, Wang, Coy et al., 2021
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CRC11 - H&E - overview - Lin, Wang, Coy et al., 2021
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CRC10 - overview - Lin, Wang, Coy et al., 2021
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CRC10 - H&E - overview - Lin, Wang, Coy et al., 2021
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CRC08 - overview - Lin, Wang, Coy et al., 2021
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CRC09 - H&E - overview - Lin, Wang, Coy et al., 2021
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CRC08 - overview - Lin, Wang, Coy et al., 2021
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CRC08 - H&E - overview - Lin, Wang, Coy et al., 2021
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CRC07 - overview - Lin, Wang, Coy et al., 2021
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CRC07 - H&E - overview - Lin, Wang, Coy et al., 2021
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CRC06 - overview - Lin, Wang, Coy et al., 2021
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CRC06 - H&E - overview - Lin, Wang, Coy et al., 2021
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CRC05 - overview - Lin, Wang, Coy et al., 2021
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CRC05 - H&E - overview - Lin, Wang, Coy et al., 2021
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CRC04 - overview - Lin, Wang, Coy et al., 2021
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CRC04 - H&E - overview - Lin, Wang, Coy et al., 2021
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CRC03 - overview - Lin, Wang, Coy et al., 2021
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CRC03 - H&E - overview - Lin, Wang, Coy et al., 2021
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CRC02 - overview - Lin, Wang, Coy et al., 2021
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CRC02 - H&E - overview - Lin, Wang, Coy et al., 2021

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