Data Explorations
Our image data can be viewed at high resolution online (without download), via Minerva. In Minerva, viewers can annotate and share regions of interest, pan and zoom to explore different levels of detail, and view different subsets of markers. Minerva stories have three main categories:
- Automated stories provide basic image viewing with automatic rendering settings, enabling rapid, lightweight sharing of highly multiplexed images, without download.
- Curated stories extend the automated stories, adding a quality control step to remove failed markers, ensure appropriate channel intensity settings, and provide metadata about the underlying sample and image.
- Narrated stories go a step further, using multi-step narrations to walk a viewer through key features of the data. Narrated stories distill the multidisciplinary knowledge encompassed by each atlas dataset into a single product that grounds the scientific analyses in the underlying data and metadata.
Narrated Minerva Stories
ERS-Low sample: enhanced immune infiltration and antigen presentation
ERS-High sample: limited immune infiltration and reduced antigen presentation
TNBC PDX (HCI-004) tumor: Vehicle Treatment
TNBC PDX (HCI-004) tumor: EZH2i/AKTi Combo Treatment Day 1
TNBC PDX (HCI-004) tumor: EZH2i/AKTi Combo Treatment Day 2
TNBC PDX (HCI-004) tumor: EZH2i/AKTi Combo Treatment Day 30
Nuclear envelope atypia and rupture in human glioblastoma
Multimodal spatial profiling of colorectal cancer using Orion
Graphical Abstract - Multiplexed 3D atlas of state transitions and immune interactions in colorectal cancer
Pathological annotations - Multiplexed 3D atlas of state transitions and immune interactions in colorectal cancer - CRC01
Exploring the Stages of Tuberculosis Granulomas
Clinical Features of Tuberculosis Granulomas
Deep Exploration of a Primary Melanoma (MEL 1 Full Story)
Introduction to the MEL Atlas (MEL 1 Abstract)
Two Ways of Immune Evasion in Early Melanoma (for non-experts)
Murine Models of Lung Adenocarcinoma
Primary Squamous Cell Carcinoma of the Lung - CyCIF (Lung 3)
Temporal and spatial topography of cell proliferation in cancer
Colorectal cancer pilot - CRC01
A7_lateral_left_ventricle
A6_posterior_left_ventricle
A5_posterior_left_ventricle
A4_posterior_left_ventricle
A3_interventricular_septum
A2_anterior_left_ventricle
A20_left_circumflex_artery
A19_left_anterior_descending_artery
A18_left_anterior_descending_artery
A17_mid_distal_right_coronary_artery
Patient 2 - Melanoma in situ, invasive melanoma, precursor field and inflammatory regression
Ovarian Cancer with Annotation - LSP15343
Ovarian Cancer with Annotation - LSP15327
BRCA wild-type TNBC vs BRCA1-associated TNBC
Clinical Benefit - Cisplatin Biopsy
Clinical Benefit - Cis Wee1i Biopsy
No Clinical Benefit - Cis Wee1i Biopsy
No Clinical Benefit - Cisplatin Biopsy
HSF1 phase transition mediates stress adaptation and cell fate decisions
Genetically engineered mouse model of lung adenocarcinoma
Pancreatic ductal adenocarcinoma (PDAC) and adjacent normal tissue (Figure 7)
Molecular heterogeneity in glioblastoma (Figure 11 and 12)
Temporal and spatial topography of cell proliferation in cancer
Tonsil - Classical features - CyCIF
Data analysis of primary lung cancer (Lung 3)
Lung squamous cell carcinoma metastasis to the brain (Lung 2)
Plexiform Schwannoma (Spinal Nerve Root)
Plexiform Schwannoma (Soft Tissue)
Plexiform Schwannoma (Soft Tissue)
Intraneural Schwannoma (Finger)
Plexiform Schwannoma (Finger)
Plexiform Schwannoma (Larynx)
Plexiform Schwannoma (Larynx)
Schwannoma (Spinal Nerve Root)
Schwannoma (Spinal Nerve Root)
Schwannoma (Spinal Nerve Root)
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Curated Minerva Stories
Curated stories provide access to images that have undergone a quality control step to remove failed markers, ensure appropriate channel intensity settings, and provide metadata about the underlying sample and image. Click the Minerva story icon for an interactive view of the full-resolution images.
Tonsil - 3D CyCIF - LSP13357
STIC-TR5 - 3D CyCIF - LSP18251
STIC-TR4 - 3D CyCIF - LSP18251
STIC-TR3 - 3D CyCIF - LSP18251
Melanoma VGP - 3D CyCIF - LSP13625
Melanoma MIS - 3D CyCIF - LSP13625
Melanoma VGP - 3D CyCIF - LSP13626
Metastatic melanoma - 3D CyCIF - LSP22409
Lung metastasis (lungMET) - 3D CyCIF - LSP22408
Glioblastoma (GBM)- 3D CyCIF - LSP17378
Cell State Dependent Effects of Bmal1 on Melanoma Immunity and Tumorigenicity
Melanoma in-situ with 3D imaging
All CyCIF sections of CRC01 (Z-stack)
TMA of 16 Breast Cancer Samples and Normal Tissue (BC03)
Lung Adenocarcinoma Metastasis to Lymph Node
Longitudinal study of metastatic melanoma - Day 92 - Skin, right upper lip (T21)
Longitudinal study of metastatic melanoma - Day 92 - Skin, left neck (T20)
Longitudinal study of metastatic melanoma - Day 92 - Skin, left groin (T19)
Longitudinal study of metastatic melanoma - Day 76 - Skin, left leg (T15)
Longitudinal study of metastatic melanoma - Day 76 - Skin, right nasal labial fold (T17)
Longitudinal study of metastatic melanoma - Day 76 - Skin, right neck (T16)
Longitudinal study of metastatic melanoma - Day 62 - Skin, left wrist (T14)
Longitudinal study of metastatic melanoma - Day 62 - Skin, right neck (T13)
Longitudinal study of metastatic melanoma - Day 39 - Skin, left arm (T12)
Longitudinal study of metastatic melanoma - Day 39 - Skin, posterior neck (T10)
Longitudinal study of metastatic melanoma - Day 39 - Skin, left scalp (T11)
Longitudinal study of metastatic melanoma - Day 39 - Skin, right scalp (T9)
Longitudinal study of metastatic melanoma - Day 27 - Skin, right ear (T8)
Longitudinal study of metastatic melanoma - Day 27 - Skin, left brow (T7)
Longitudinal study of metastatic melanoma - Day 27 - Skin, chin (T5)
Longitudinal study of metastatic melanoma - Day 27 - Skin, upper lip (T6)
Longitudinal study of metastatic melanoma - Day -22 - Skin, nasal labial fold (T4)
Longitudinal study of metastatic melanoma - Day 1028 - Jejunal resection (R1)
Longitudinal study of metastatic melanoma - Day 109 - skin, left ring finger (T22)
Longitudinal study of metastatic melanoma - Day 83 - skin left shoulder (T18)
Longitudinal study of metastatic melanoma - Day 1862 - skin left neck (R3.2)
Longitudinal study of metastatic melanoma - Day 1849 - skin left neck (R3.1)
Ovarian cancer with metadata - LSP15343
CK19_BCC2 (BRCA wildtype)
All 25 CyCIF sections from CRC01 (array)
All 22 H&E sections from CRC01 (array)
Metastatic melanoma lesion and adjacent benign tissue (Figure 2)
CyCIF of TMA with normal and tumor tissue (Figure 10)
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Automated Minerva Stories
Automated stories provide basic image viewing with automatic rendering settings, enabling rapid, lightweight sharing of highly multiplexed images, without download. Click the Minerva story icon for an interactive view of the full-resolution images.
Orion CRC40 - overview - Lin, Chen, Campton et al., 2023
Orion CRC39 - overview - Lin, Chen, Campton et al., 2023
Orion CRC38 - overview - Lin, Chen, Campton et al., 2023
Orion CRC37 - overview - Lin, Chen, Campton et al., 2023
Orion CRC36 - overview - Lin, Chen, Campton et al., 2023
Orion CRC35 - overview - Lin, Chen, Campton et al., 2023
Orion CRC34 - overview - Lin, Chen, Campton et al., 2023
Orion CRC33_02 - overview - Lin, Chen, Campton et al., 2023
Orion CRC33_01 - overview - Lin, Chen, Campton et al., 2023
Orion CRC32 - overview - Lin, Chen, Campton et al., 2023
Orion CRC31 - overview - Lin, Chen, Campton et al., 2023
Orion CRC30 - overview - Lin, Chen, Campton et al., 2023
Orion CRC29 - overview - Lin, Chen, Campton et al., 2023
Orion CRC28 - overview - Lin, Chen, Campton et al., 2023
Orion CRC27 - overview - Lin, Chen, Campton et al., 2023
Orion CRC26 - overview - Lin, Chen, Campton et al., 2023
Orion CRC25 - overview - Lin, Chen, Campton et al., 2023
Orion CRC24 - overview - Lin, Chen, Campton et al., 2023
Orion CRC23 - overview - Lin, Chen, Campton et al., 2023
Orion CRC21 - overview - Lin, Chen, Campton et al., 2023
Orion CRC08 - overview - Lin, Chen, Campton et al., 2023
Orion CRC20 - overview - Lin, Chen, Campton et al., 2023
Orion CRC19 - overview - Lin, Chen, Campton et al., 2023
Orion CRC18 - overview - Lin, Chen, Campton et al., 2023
Orion CRC17 - overview - Lin, Chen, Campton et al., 2023
Orion CRC16 - overview - Lin, Chen, Campton et al., 2023
Orion CRC15 - overview - Lin, Chen, Campton et al., 2023
Orion CRC14 - overview - Lin, Chen, Campton et al., 2023
Orion CRC13 - overview - Lin, Chen, Campton et al., 2023
Orion CRC12 - overview - Lin, Chen, Campton et al., 2023
Orion CRC11 - overview - Lin, Chen, Campton et al., 2023
Orion CRC10 - overview - Lin, Chen, Campton et al., 2023
Orion CRC09 - overview - Lin, Chen, Campton et al., 2023
Orion CRC07 - overview - Lin, Chen, Campton et al., 2023
Orion CRC06 - overview - Lin, Chen, Campton et al., 2023
Orion CRC05 - overview - Lin, Chen, Campton et al., 2023
Orion CRC04 - overview - Lin, Chen, Campton et al., 2023
Orion CRC03 - overview - Lin, Chen, Campton et al., 2023
Orion CRC02 - overview - Lin, Chen, Campton et al., 2023
Orion CRC01 - overview - Lin, Chen, Campton et al., 2023
Lung adenocarcinoma - P138007
Lung adenocarcinoma - P137974
Lung adenocarcinoma - P137941
Lung adenocarcinoma - P137905
Lung adenocarcinoma - P137757
Lung adenocarcinoma - P137753
Lung adenocarcinoma - P137591
Lung adenocarcinoma - P136690
Lung adenocarcinoma - P133537
Lung adenocarcinoma - P132666
Lung adenocarcinoma - P132630
Lung adenocarcinoma - P132115
MEL13-2-1 - overview - Nirmal, Maliga, Vallius, Sorger et al., 2021
MEL13-2-0 - H&E - overview - Nirmal, Maliga, Vallius, Sorger et al., 2021
MEL13-1-1 - overview - Nirmal, Maliga, Vallius, Sorger et al., 2021
MEL13-1-0 - H&E - overview - Nirmal, Maliga, Vallius, Sorger et al., 2021
MEL12-1-1 - overview - Nirmal, Maliga, Vallius, Sorger et al., 2021
MEL12-1-0 - H&E - overview - Nirmal, Maliga, Vallius, Sorger et al., 2021
MEL11-1-1 - overview - Nirmal, Maliga, Vallius, Sorger et al., 2021
MEL11-1-0 - H&E - overview - Nirmal, Maliga, Vallius, Sorger et al., 2021
MEL10-1-1 - overview - Nirmal, Maliga, Vallius, Sorger et al., 2021
MEL10-1-0 - H&E - overview - Nirmal, Maliga, Vallius, Sorger et al., 2021
MEL09-1-1 - overview - Nirmal, Maliga, Vallius, Sorger et al., 2021
MEL09-1-0 - H&E - overview - Nirmal, Maliga, Vallius, Sorger et al., 2021
MEL08-1-1 - overview - Nirmal, Maliga, Vallius, Sorger et al., 2021
MEL08-1-0 - H&E - overview - Nirmal, Maliga, Vallius, Sorger et al., 2021
MEL07-1-1 - overview - Nirmal, Maliga, Vallius, Sorger et al., 2021
MEL07-1-0 - H&E - overview - Nirmal, Maliga, Vallius, Sorger et al., 2021
MEL06-1-1 - overview - Nirmal, Maliga, Vallius, Sorger et al., 2021
MEL06-1-0 - H&E - overview - Nirmal, Maliga, Vallius, Sorger et al., 2021
MEL05-1-1 - overview - Nirmal, Maliga, Vallius, Sorger et al., 2021
MEL05-1-0 - H&E - overview - Nirmal, Maliga, Vallius, Sorger et al., 2021
MEL04-1-1 - overview - Nirmal, Maliga, Vallius, Sorger et al., 2021
MEL04-1-0 - H&E - overview - Nirmal, Maliga, Vallius, Sorger et al., 2021
MEL03-1-1 - overview - Nirmal, Maliga, Vallius, Sorger et al., 2021
MEL03-1-0 - H&E - overview - Nirmal, Maliga, Vallius, Sorger et al., 2021
MEL02-1-1 - overview - Nirmal, Maliga, Vallius, Sorger et al., 2021
MEL02-1-0 - H&E - overview - Nirmal, Maliga, Vallius, Sorger et al., 2021
MEL01-3-1 - overview - Nirmal, Maliga, Vallius, Sorger et al., 2021
MEL01-3-0 - H&E - overview - Nirmal, Maliga, Vallius, Sorger et al., 2021
MEL01-2-1 - overview - Nirmal, Maliga, Vallius, Sorger et al., 2021
MEL01-2-0 - H&E - overview - Nirmal, Maliga, Vallius, Sorger et al., 2021
MEL01-1-6 - overview - Nirmal, Maliga, Vallius, Sorger et al., 2021
MEL01-1-5 - overview - Nirmal, Maliga, Vallius, Sorger et al., 2021
MEL01-1-4 - overview - Nirmal, Maliga, Vallius, Sorger et al., 2021
MEL01-1-3 - overview - Nirmal, Maliga, Vallius, Sorger et al., 2021
MEL01-1-1 - overview - Nirmal, Maliga, Vallius, Sorger et al., 2021
MEL01-1-0 - H&E - overview - Nirmal, Maliga, Vallius, Sorger et al., 2021
Longitudinal study of metastatic melanoma - Autopsy - Right adrenal (AV1)
Longitudinal study of metastatic melanoma - Autopsy - Subcutaneous lesion, left temporal bone (AS4)
Longitudinal study of metastatic melanoma - Autopsy - Subcutaneous lesion, left scalp (AS3)
Longitudinal study of metastatic melanoma - Autopsy - Subcutaneous lesion, left inguinal region (AS2)
Longitudinal study of metastatic melanoma - Autopsy - Subcutaneous lesion, left mastoid (AS1)
Longitudinal study of metastatic melanoma - Autopsy - Lung, left lower lobe (AL4)
Longitudinal study of metastatic melanoma - Autopsy - Lung, left upper lobe (AL3)
Longitudinal study of metastatic melanoma - Autopsy - Lung, right upper lobe (AL2)
Longitudinal study of metastatic melanoma - Autopsy - Lung, right lower lobe (AL1)
Patient 1 - Melanoma with precursor fields
Patient 2 - Inflammatory regression and brisk TILs
Patient 2 - Melanoma in situ, invasive and polypoid melanoma
BRCA wild-type TNBC (BRCA-WT-6)
BRCA wild-type TNBC (BRCA-WT-5)
BRCA wild-type TNBC (BRCA-WT-4)
BRCA wild-type TNBC (BRCA-WT-3)
BRCA wild-type TNBC (BRCA-WT-2)
BRCA wild-type TNBC (BRCA-WT-1)
CRC18 - H&E - overview - Lin, Wang, Coy et al., 2021
CRC17 - overview - Lin, Wang, Coy et al., 2021
CRC17 - H&E - overview - Lin, Wang, Coy et al., 2021
CRC16 - overview - Lin, Wang, Coy et al., 2021
CRC16 - H&E - overview - Lin, Wang, Coy et al., 2021
CRC15 - overview - Lin, Wang, Coy et al., 2021
CRC15 - H&E - overview - Lin, Wang, Coy et al., 2021
CRC14 - overview - Lin, Wang, Coy et al., 2021
CRC14 - H&E - overview - Lin, Wang, Coy et al., 2021
CRC13 - overview - Lin, Wang, Coy et al., 2021
CRC13 - H&E - overview - Lin, Wang, Coy et al., 2021
CRC12 - overview - Lin, Wang, Coy et al., 2021
CRC12 - H&E - overview - Lin, Wang, Coy et al., 2021
CRC11 - overview - Lin, Wang, Coy et al., 2021
CRC11 - H&E - overview - Lin, Wang, Coy et al., 2021
CRC10 - overview - Lin, Wang, Coy et al., 2021
CRC10 - H&E - overview - Lin, Wang, Coy et al., 2021
CRC08 - overview - Lin, Wang, Coy et al., 2021
CRC09 - H&E - overview - Lin, Wang, Coy et al., 2021
CRC08 - overview - Lin, Wang, Coy et al., 2021
CRC08 - H&E - overview - Lin, Wang, Coy et al., 2021
CRC07 - overview - Lin, Wang, Coy et al., 2021
CRC07 - H&E - overview - Lin, Wang, Coy et al., 2021
CRC06 - overview - Lin, Wang, Coy et al., 2021
CRC06 - H&E - overview - Lin, Wang, Coy et al., 2021
CRC05 - overview - Lin, Wang, Coy et al., 2021
CRC05 - H&E - overview - Lin, Wang, Coy et al., 2021
CRC04 - overview - Lin, Wang, Coy et al., 2021
CRC04 - H&E - overview - Lin, Wang, Coy et al., 2021
CRC03 - overview - Lin, Wang, Coy et al., 2021
CRC03 - H&E - overview - Lin, Wang, Coy et al., 2021
CRC02 - overview - Lin, Wang, Coy et al., 2021
CRC02 - H&E - overview - Lin, Wang, Coy et al., 2021
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