Data

Tuberculosis Granuloma Atlas

The Tuberculosis Granuloma Atlas aims to understand the biology of granulomas, sites of chronic lung inflammation shaped by the biology Mycobacterium tuberculosis (Mtb) and host immune responses. Within a granuloma, Mtb growth is often limited, but this provides a niche from which bacteria can subsequently disseminate. The project also aims to build capacity for digital pathology in low and middle income countries (LIMC) including the eventual deployment of Atlas viewers and analysis modules on cell phones. As part of the Atlas, LSP investigators are assembling a cloud-based Tuberculosis Data Resource that will consolidate a rich collection of imaging and genomic data on TB granulomas and make the data publicly available.

Principal Investigators

Bree Aldridge, PhD, Associate Professor, Molecular Biology and Microbiology, Tufts University School of Medicine
Amanda Martinot, DVM MPH DACVP, Assistant Professor of Infectious Diseases and Global Health, Tufts University
Jyothi Rengarajan, PhD, Professor, Division of Infectious Diseases, Emory University School of Medicine
Peter Sorger, PhD, Professor of Systems Biology, Harvard Medical School

Introduction to TB Granuloma

Introduction

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Bree Aldridge, PhD introducing the biology behind the Tuberculosis Granuloma Atlas.

Data Explorations

Clinical Features of Tuberculosis Granulomas

Exploring the Stages of Tuberculosis Granulomas

Data Overviews

Data Overviews provide access to minimally processed Level 2 images with no annotation or quality control. Click any of the following thumbnail images for an interactive view of the full-resolution images. These are currently all MIBI images.

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Funding

The Atlas is part of a sustained effort by the Bill and Melinda Gates Foundation to understand and ultimately eradicate TB (Funded by Grant INV-027106) and NIH 1R01-AI166305.