People

Faculty and Principal Investigators

Peter Sorger, PhD - photo

Peter Sorger, PhD

  • Otto Krayer Professor of Systems Biology, Harvard Medical School
  • Head of the Harvard Program in Therapeutic Sciences
  • Founding Director of the Laboratory of Systems Pharmacology

Peter Sorger, PhD is co-director of the Harvard Tissue Atlas and founding director of its Laboratory of Systems Pharmacology (LSP), where most of the HTA is based. The focus of his research is on understanding the signal transduction and cell survival networks whose mutation causes cancer and determines responsiveness to therapy. His group combines experimental and computational biology to study cultured cells, animal models, and human specimens with a particular focus on cell-intrinsic and extrinsic oncogenic mechanisms. His group also works to advance the interpretation and stratification of human clinical trial results. As part of the HTA, Peter works to link new data collection methods with the development of algorithms and computational pipelines for interpreting the resulting multi-modal single cell data.

Sandro Santagata, MD, PhD - photo

Sandro Santagata, MD, PhD

  • Associate Professor in Pathology, Harvard Medical School
  • Neuropathologist in the Department of Pathology, Brigham and Women’s Hospital

Sandro Santagata, MD, PhD is co-director of the Harvard Tissue Atlas and a practicing neuropathologist in the Brigham and Women’s Hospital specializing in adult and pediatric brain tumors. Dr. Santagata’s research aims to identify and target vulnerabilities in tumors to improve patient outcome and survival, focusing on primary brain tumors and tumors that metastasize to the brain. Through genomics, chemical biology, and multiplexed imaging his laboratory explores the fundamental mechanisms that allow tumor cells to develop their most malignant features along with colleagues in the Laboratory of Systems Pharmacology.

Bree Aldridge, PhD - photo

Bree Aldridge, PhD

  • Associate Professor of Molecular Biology and Microbiology, Tufts University School of Medicine
  • Associate Professor, Biomedical Engineering, Tufts University School of Engineering

Bree Aldridge, PhD, is an Associate Professor of Molecular Biology and Microbiology and Biomedical Engineering at Tufts University who’s research focuses on designing optimized therapies for TB using cell biology and engineering approaches. The [Aldridge Lab] (https://sites.tufts.edu/aldridgelab/) is a multidisciplinary research team, integrating quantitative measurement with computational modeling and analysis to create intuitive descriptions of complex cell biology. The lab focuses on characterizing single-cell determinants of mycobacterial drug tolerance, understanding how growth heterogeneity is controlled, and engineering combination therapy.

Jennifer Guerriero, PhD - photo

Jennifer Guerriero, PhD

  • Assistant Professor, Harvard Medical School
  • Director of the Breast Immunology Laboratory, Dana-Farber Cancer Institute

Jennifer Guerriero, PhD is a cancer biologist who leads the Breast Immunology Laboratory in the Women’s Cancer Program at Dana-Farber Cancer Institute and Brigham and Women’s Hospital. Her research focuses on unraveling the complexity of tissue associated macrophages and their roles in cancer surveillance and progression (TAMs). She and her group study the functions, regulation, and developmental identities of TAMs and perform basic science and translational experiments aimed at identifying clinically effective strategies for targeting TAMs, thereby promoting T-cell activation and weakening the immune-suppressive properties of the tumor microenvironment.

Jia-Ren Lin, PhD - photo

Jia-Ren Lin, PhD

  • Technical Director of Tissue Imaging, Laboratory of Systems Pharmacology

Jerry Lin is the inventor of the cyclic immunofluorescence (CyCIF) methods for performing highly-multiplexed, high-resolution imaging of cells and tissues. He leads the development and testing of new methods for increasing the sensitivity, throughout, and information content of high-plex tissue imaging. He also leads projects investigating progression and drug responses in breast and colorectal cancer.

Zoltan Maliga, PhD - photo

Zoltan Maliga, PhD

  • Scientific Director of Tissue Imaging, Laboratory of Systems Pharmacology

Zoltan Maliga, PhD is an experienced cell biologist and immunologist who, as an NCI Research Specialist, co-leads the tissue imaging platform at the Laboratory of Systems Pharmacology. Zoltan focuses on tumor-immune interactions and leads and effort to understand the origins of adverse response to immunotherapies. This involves improving our understanding of immune homeostasis in epithelia and its breakdown in idiopathic skin diseases and following immune checkpoint therapy as well as the relationship of these phenomena to the treatment of skin cancer.

Hanspeter Pfister, PhD - photo

Hanspeter Pfister, PhD

  • An Wang Professor of Computer Science, Harvard John A. Paulson School of Engineering and Applied Sciences
  • Academic Dean of Computational Sciences and Engineering, Harvard University

Hanspeter Pfister is the founder and director of the Visual Computing Group (VCG) at Harvard’s School of Engineering and Applied Sciences. He is an expert in the development of visual analysis tools and methods used to improve how we process complex, multi-dimensional data sets in domains such as neuroscience, genomics, systems biology, astronomy, and medicine. Hanspeter leads the LSP’s effort in the application of machine learning and AI to tissue images.

Research Scientists and Associates

Sarah Arena, MLIS - photo

Sarah Arena, MLIS

  • Data Manager, Laboratory of Systems Pharmacology
Raquel Arias-Camison, BS - photo

Raquel Arias-Camison, BS

  • Research Project Manager, Laboratory of Systems Pharmacology
Alyce Chen, PhD - photo

Alyce Chen, PhD

  • Scientific Program Manager, Laboratory of Systems Pharmacology
Yu-An Chen, MSc - photo

Yu-An Chen, MSc

  • Research Scientist, Laboratory of Systems Pharmacology
Benjamin Gaudio, BS - photo

Benjamin Gaudio, BS

  • Research Technician, Laboratory of Systems Pharmacology
John Hoffer, BS - photo

John Hoffer, BS

  • Software Engineer, Laboratory of Systems Pharmacology
Robert Krueger, PhD - photo

Robert Krueger, PhD

  • Research Scientist, Sorger Lab, Harvard Medical School
  • Research Scientist, Pfister Lab, Harvard School of Engineering and Applied Sciences
Allison Maier, MLIS - photo

Allison Maier, MLIS

  • Data Curator, Laboratory of Systems Pharmacology
Jeremy Muhlich, BA - photo

Jeremy Muhlich, BA

  • Director of Software Engineering, Laboratory of Systems Pharmacology
Roxanne Pelletier, MS - photo

Roxanne Pelletier, MS

  • CyCIF Scientist, Laboratory of Systems Pharmacology
Kenichi Shimada, PhD - photo

Kenichi Shimada, PhD

  • Research Associate, Breast Tumor Immunology Lab, Dana-Farber Cancer Institute
  • Research Associate, Ludwig Center at Harvard
Artem Sokolov, PhD - photo

Artem Sokolov, PhD

  • Director of Modeling and Informatics, Laboratory of Systems Pharmacology
  • Instructor in Biomedical Informatics, Harvard Medical School
Juliann Tefft, PhD - photo

Juliann Tefft, PhD

  • Scientific Communication Fellow, Laboratory of Systems Pharmacology
Clarence Yapp, DPhil - photo

Clarence Yapp, DPhil

  • Director of Microscopy and Computer Vision, Laboratory of Systems Pharmacology

Fellows and Students

Gregory Baker, PhD - photo

Gregory Baker, PhD

  • Postdoctoral Fellow, Laboratory in Systems Pharmacology
Ajit Johnson Nirmal, PhD - photo

Ajit Johnson Nirmal, PhD

  • Independent Postdoctoral Fellow, Weinstock Lab, Dana-Farber Cancer Institute
  • Independent Postdoctoral Fellow, Sorger Lab, Harvard Medical School
  • Instructor of Medicine, Harvard Medical School
Shishir Pant, PhD - photo

Shishir Pant, PhD

  • Postdoctoral Fellow, Sorger Lab, Harvard Medical School
Tuulia Vallius, MD, PhD - photo

Tuulia Vallius, MD, PhD

  • Postdoctoral Fellow, Laboratory of Systems Pharmacology
  • Medical Oncology Fellow, Turku University Hospital & University of Turku, Finland
Han Xu, PhD - photo

Han Xu, PhD

  • Education Fellow in Therapeutic Science, Harvard Program in Therapeutic Science

Alumni

Benjamin Izar, MD, PhD - photo

Benjamin Izar, MD, PhD

  • Assistant Professor, Herbert Irving Comprehensive Cancer Center, Columbia University

The Izar Laboratory investigates interactions between cancer and immune cells during tumor development, metastasis and drug resistance using high-dimensional functional single-cell genomics and imaging. The ultimate goal of this work is to inform better selection and development of therapies to improve the lives of cancer patients.

Connor Jacobson, BS - photo

Connor Jacobson, BS

  • Research Assistant, Laboratory of Systems Pharmacology
Shaolin Mei - photo

Shaolin Mei

  • Graduate Research Assistant, Laboratory of Systems Pharmacology
Rumana Rashid, MS - photo

Rumana Rashid, MS

  • Scientist, Laboratory of Systems Pharmacology
Douglas Russell - photo

Douglas Russell

  • Research Associate, Sorger Lab, Harvard Medical School
Denis Schapiro, PhD - photo

Denis Schapiro, PhD

  • Group Leader, Heidelberg University Hospital

The Schapiro Lab builds computational and experimental tools to develop new insight into the organization and functions of normal and diseased tissue. The resulting information is combined with functional assays to better understand, diagnose, and treat diseases such as cancer.

Madison Tyler, MS - photo

Madison Tyler, MS

  • CyCIF Scientist, Laboratory of Systems Pharmacology

collaborators

Alan d’Andrea, MD

Jon Aster, MD, PhD

Pratiti (Mimi) Bandopadhayay, MBBS, PhD

David Barbie, MD

Joan Brugge PhD,

Ethan Cerami, PhD

George Demetri, MD

Benjamin Levine Ebert, MD, PhD

William Freed-Pastor, MD, PhD

Leena Gandhi, MD, PhD

Todd R. Golub, MD

Matthew L. Hemming, MD, PhD

Pasi A. Jänne, MD, PhD

Rinath Jeselsohn, MD

Sheheryar Kabraji, BM BCh

Keith Ligon, MD, PhD

David Liu, MD

Amanda Martinot PhD, MPH, DVM,

Franziska Michor, PhD

Elizabeth Mittendorf, MD, PhD

David Pellman, MD

David A. Reardon, MD

Geoffrey Shapiro, MD, PhD

Alex Spektor, MD, PhD

Sara M. Tolaney, MD, MPH

David M. Weinstock, MD

Patrick Y. Wen, MD

Kai W. Wucherpfennig, MD, PhD

Jean Zhao, PhD