Talk given on March 11, 2024 by Jeremy Muhlich (Harvard Medical School) for the Computation Center for Biomedicine (CCB) Seminar Series at Harvard Medical School about image processing and analysis using the MCMICRO software pipeline.

Talk given by Shannon Coy, M.D. (Brigham and Women’s Hospital) for the 2024 David Liposarcoma Research Symposium on March 6, 2024.

During this presentation of the Cancer Moonshot Seminar Series, Sandro Santagata, M.D., Ph.D. (Brigham and Women’s Hospital) discusses multiplexed tissue imaging to reveal the spatial biology of tumors. This work is related to the Blue Ribbon Panel recommendation to generate human tumor atlases.

This interview with Sandro Santagata, MD PhD, and Sarah Arena, MLIS, dive into the vision for the Gray BRCA Pre-Cancer Atlas.

Bree Aldridge, PhD, Associate Professor at Tufts University School of Medicine and Tufts University School of Engineering, introduces the Tuberculosis Tumor Atlas.

This interview with Dr. Joan Brugge describes her breast cancer research collected as part of the Gray BRCA Pre-Cancer Atlas.

This interview with Drs. Ronny Drapkin and Tanjina Kader describes preliminary ovarian cancer research collected as part of the Gray BRCA Pre-Cancer Atlas.

This AACR Journal Club discusses features Peter Sorger, PhD, discussing his article “The Spatial Landscape of Progression and Immunoediting in Primary Melanoma at Single-Cell Resolution.” The intricacies of primary melanoma progression are revealed by a combination of high-plex imaging, 3D high-resolution microscopy, and spatially resolved microregion transcriptomics. Dr. Sorger shows that this unprecedented spatiotemoporal resolution uncovers recurrent cellular neighborhoods and the landscape of immune evasion and immunoediting.

This webinar presents two projects from the Ludwig Centers at Harvard and MIT that are part of the Ludwig Tumor Atlas Project. The Ludwig Tumor Atlas applies diverse technologies to probe the tumor environment using a variety of methods, including highly multiplexed tissue imaging, dissociative single cell sequencing, spatial transcriptomics and conventional histology.

Zoltan Maliga, PhD, Scientific Director of Tissue Imaging at the Laboratory of Systems Pharmacology, describes using multiplexed fluorescent tissue imaging to characterize Formalin-Fixed Paraffin-Embedded (FFPE) tissues.

MCMICRO is an open source automated end-to-end image analysis pipeline designed for large tissue images and high content imaging.

Minerva is a suite of software tools for tissue atlases and digital pathology that enables interactive viewing and fast sharing of large image data. It comprises of Minerva Author, a tool that lets you easily create and annotate images, and Minerva Story, a narrative image viewer for web hosting.