Tissue and tumor atlases revolutionize our understanding of disease progression and therapeutic response. They provide precise molecular data on cell types, states, and interactions in a preserved 3D environment to improve diagnosis and disease management.
Navigating Spatial Biology
The Harvard Tissue Atlas (HTA) gathers together image and omic datasets into molecular maps. Our atlases bring together multiple research projects examining normal and diseased tissue from human and animal models, with an emphasis on cancer. The goal of these atlases is to describe the myriad of interactions that occur between cells and acellular structures within tissues to advance our understanding of disease initiation and progression. This will help develop a new generation of diagnostic molecular tests, which are needed for disease stratification in clinical trials and precision medicine for patients.
News
A New Tool for Diagnosing Cancer
News
Ludwig Harvard team devises platform to bring “multiplex” imaging to the clinical pathology laboratory
News
New 3D Atlas of Colorectal Cancer Promises Improved Diagnosis, Treatment
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Ludwig Harvard imaging study reveals cellular, molecular and structural complexity of colorectal tumors
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2D and 3D Maps Provide New Insight Into Colorectal Cancer
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3D Spatial Colorectal Cancer Maps Combine Molecular and Histological Features
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An Unprecedented Look at Colorectal Cancer
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Data Deep Dive
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Getting Under Our Skin
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Atlas maker: Q & A with Peter Sorger
News
Publications & Software
High-plex immunofluorescence imaging and traditional histology of the same tissue section for discovering image-based biomarkers
Publication
Multiplexed 3D atlas of state transitions and immune interaction in colorectal cancer
Publication
Spatial intra-tumor heterogeneity is associated with survival of lung adenocarcinoma patients
Publication
Minerva
A suite of software tools for interpreting, interacting with, and sharing complex image data.
Software
The spatial landscape of progression and immunoediting in primary melanoma at single cell resolution
Publication
Software
MCMICRO: A multiple-choice microscopy pipeline
An end-to-end processing pipeline for multiplexed whole tissue imaging and tissue microarrays.
Publication
Software
Featured Atlas/Data
Graphical Abstract - Multiplexed 3D atlas of state transitions and immune interactions in colorectal cancer
Exploring the Stages of Tuberculosis Granulomas
Patient 2 - Melanoma in situ, invasive melanoma, precursor field and inflammatory regression
Deep Exploration of a Primary Melanoma (MEL 1 Full Story)
Genetically engineered mouse model of lung adenocarcinoma
Temporal and spatial topography of cell proliferation in cancer
Lung 3 Data Analysis - Du and Lin et al
Multimodal spatial profiling of colorectal cancer using Orion