Tissue and tumor atlases revolutionize our understanding of disease progression and therapeutic response. They provide precise molecular data on cell types, states, and interactions in a preserved 3D environment to improve diagnosis and disease management.
Navigating Spatial Biology
The Harvard Tissue Atlas (HTA) gathers together image and omic datasets into molecular maps. Our atlases bring together multiple research projects examining normal and diseased tissue from human and animal models, with an emphasis on cancer. The goal of these atlases is to describe the myriad of interactions that occur between cells and acellular structures within tissues to advance our understanding of disease initiation and progression. This will help develop a new generation of diagnostic molecular tests, which are needed for disease stratification in clinical trials and precision medicine for patients.
News
![Thumbnail image for news item](https://tissue-atlas-org.imgix.net/publications/multiplexed-3D-atlas-of-state-transitions-and-immune-interactions-in-colorectal-cancer-graphic-abstract.png?w=259&h=176&fit=crop)
'Multiplexed 3D atlas' selected as the Best of Cell 2023
News
![Thumbnail image for news item](https://tissue-atlas-org.imgix.net/publications/High-plex-immunofluorescence-imaging-and-traditional-histology-of-the-same-tissue-section-for-discovering-image-based-biomarkers-1.png?w=259&h=176&fit=crop)
'High-plex immunofluorescence imaging' featured in Nature Cancer’s 2023 in Review
News
![Thumbnail image for news item](https://tissue-atlas-org.imgix.net/news/live-cell-imaging-id-news.png?w=259&h=176&fit=crop)
Live Cell Imaging IDs Bad Actors in Cancer and Finds Possible Ways to Defeat Them
News
![Thumbnail image for news item](https://tissue-atlas-org.imgix.net/publications/A-new-tool-for-diagnosing-cancer.jpg?w=259&h=176&fit=crop)
A New Tool for Diagnosing Cancer
News
![Thumbnail image for news item](https://tissue-atlas-org.imgix.net/publications/New-3D-Atlas-NIH-directors-blog.png?w=259&h=176&fit=crop)
New 3D Atlas of Colorectal Cancer Promises Improved Diagnosis, Treatment
News
![Thumbnail image for news item](https://tissue-atlas-org.imgix.net/publications/Ludwig-Harvard-imaging-study-reveals-cellular-molecular-and-structural-complexity-of-colorectal-tumors.png?w=259&h=176&fit=crop)
Ludwig Harvard imaging study reveals cellular, molecular and structural complexity of colorectal tumors
News
![Thumbnail image for news item](https://tissue-atlas-org.imgix.net/publications/An-Unprecedented-Look-at-Colorectal-Cancer.jpg?w=259&h=176&fit=crop)
An Unprecedented Look at Colorectal Cancer
News
Getting Under Our Skin
News
Publications & Software
![Thumbnail image for news item](https://tissue-atlas-org.imgix.net/publications/development-and-validation-of-time-to-event-models-to-predict-metastatic-recurrence-of-localized-cutaneous-melanoma.png?w=259&h=176&fit=crop)
Development and validation of time-to-event models to predict metastatic recurrence of localized cutaneous melanoma
Publication
![Thumbnail image for news item](https://tissue-atlas-org.imgix.net/publications/guerriero-lin-santagata-2023-compressed.png?w=259&h=176&fit=crop)
Qualification of a multiplexed tissue imaging assay and detection of novel patterns of HER2 heterogeneity in breast cancer
Publication
![Thumbnail image for news item](https://tissue-atlas-org.imgix.net/publications/High-plex-immunofluorescence-imaging-and-traditional-histology-of-the-same-tissue-section-for-discovering-image-based-biomarkers-1.png?w=259&h=176&fit=crop)
High-plex immunofluorescence imaging and traditional histology of the same tissue section for discovering image-based biomarkers
Publication
Multiplexed 3D atlas of state transitions and immune interaction in colorectal cancer
Publication
![Thumbnail image for news item](https://tissue-atlas-org.imgix.net/publications/spatial-intra-tumor-heterogeneity-is-associated-with-survival-of-lung-adenocarcimoma-patients.jpg?w=259&h=176&fit=crop)
Spatial intra-tumor heterogeneity is associated with survival of lung adenocarcinoma patients
Publication
![Thumbnail image for news item](https://tissue-atlas-org.imgix.net/software/minerva_v2.png?w=259&h=176&fit=crop)
Minerva
A suite of software tools for interpreting, interacting with, and sharing complex image data.
Software
![Thumbnail image for news item](https://tissue-atlas-org.imgix.net/publications/the-spatial-landscape-of-progression-and-immunoediting-in-primary-melanoma-at-single-cell-resolution_v2.png?w=259&h=176&fit=crop)
The spatial landscape of progression and immunoediting in primary melanoma at single cell resolution
Publication
Software
![Thumbnail image for news item](https://tissue-atlas-org.imgix.net/news/mcmicro.jpg?w=259&h=176&fit=crop)
MCMICRO: A multiple-choice microscopy pipeline
An end-to-end processing pipeline for multiplexed whole tissue imaging and tissue microarrays.
Publication
Software
Featured Atlas/Data
![Data image](https://www.cycif.org/assets/img/lin-wang-coy-2021/viz.jpg)