Tissue and tumor atlases revolutionize our understanding of disease progression and therapeutic response. They provide precise molecular data on cell types, states, and interactions in a preserved 3D environment to improve diagnosis and disease management.
Navigating Spatial Biology
The Harvard Tissue Atlas (HTA) gathers together image and omic datasets into molecular maps. Our atlases bring together multiple research projects examining normal and diseased tissue from human and animal models, with an emphasis on cancer. The goal of these atlases is to describe the myriad of interactions that occur between cells and acellular structures within tissues to advance our understanding of disease initiation and progression. This will help develop a new generation of diagnostic molecular tests, which are needed for disease stratification in clinical trials and precision medicine for patients.
News

Live Cell Imaging IDs Bad Actors in Cancer and Finds Possible Ways to Defeat Them
News

A New Tool for Diagnosing Cancer
News

New 3D Atlas of Colorectal Cancer Promises Improved Diagnosis, Treatment
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Ludwig Harvard imaging study reveals cellular, molecular and structural complexity of colorectal tumors
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An Unprecedented Look at Colorectal Cancer
News

Data Deep Dive
News
Getting Under Our Skin
News

Atlas maker: Q & A with Peter Sorger
News
Publications & Software

High-plex immunofluorescence imaging and traditional histology of the same tissue section for discovering image-based biomarkers
Publication
Multiplexed 3D atlas of state transitions and immune interaction in colorectal cancer
Publication

Spatial intra-tumor heterogeneity is associated with survival of lung adenocarcinoma patients
Publication

Minerva
A suite of software tools for interpreting, interacting with, and sharing complex image data.
Software

The spatial landscape of progression and immunoediting in primary melanoma at single cell resolution
Publication
Software



MCMICRO: A multiple-choice microscopy pipeline
An end-to-end processing pipeline for multiplexed whole tissue imaging and tissue microarrays.
Publication
Software