Tissue and tumor atlases revolutionize our understanding of disease progression and therapeutic response. They provide precise molecular data on cell types, states, and interactions in a preserved 3D environment to improve diagnosis and disease management.
Navigating Spatial Biology
The Harvard Tissue Atlas (HTA) gathers together image and omic datasets into molecular maps. Our atlases bring together multiple research projects examining normal and diseased tissue from human and animal models, with an emphasis on cancer. The goal of these atlases is to describe the myriad of interactions that occur between cells and acellular structures within tissues to advance our understanding of disease initiation and progression. This will help develop a new generation of diagnostic molecular tests, which are needed for disease stratification in clinical trials and precision medicine for patients.
News
New 3D Atlas of Colorectal Cancer Promises Improved Diagnosis, Treatment
News
Ludwig Harvard imaging study reveals cellular, molecular and structural complexity of colorectal tumors
News
2D and 3D Maps Provide New Insight Into Colorectal Cancer
News
3D Spatial Colorectal Cancer Maps Combine Molecular and Histological Features
News
An Unprecedented Look at Colorectal Cancer
News
Data Deep Dive
News
Getting Under Our Skin
News
Atlas maker: Q & A with Peter Sorger
News
Publications & Software
Multiplexed 3D atlas of state transitions and immune interaction in colorectal cancer
Publication
Spatial intra-tumor heterogeneity is associated with survival of lung adenocarcinoma patients
Publication
Minerva
A suite of software tools for interpreting, interacting with, and sharing complex image data.
Software
The spatial landscape of progression and immunoediting in primary melanoma at single cell resolution
Publication
Software
MCMICRO: A multiple-choice microscopy pipeline
An end-to-end processing pipeline for multiplexed whole tissue imaging and tissue microarrays.
Publication
Software
Featured Atlas/Data
Exploring the Stages of Tuberculosis Granulomas
Patient 2 - Melanoma in situ, invasive melanoma, precursor field and inflammatory regression
Deep Exploration of a Primary Melanoma (MEL 1 Full Story)
Multiplexed 3D atlas of state transitions and immune interactions in colorectal cancer (Graphical Abstract)
Genetically engineered mouse model of lung adenocarcinoma
Temporal and spatial topography of cell proliferation in cancer
Lung 3 Data Analysis - Du and Lin et al
Plexiform Schwannoma (Larynx)